反应详情

5-Chloro-2-trifluoromethyl[1,8]naphthyridine (100 mg, 0.43 mmol) was coupled to 4-fluoro-3-(pyridin-4-yl)benzeneboronic acid (121 mg, 0.56 mmol) as described in Example 3 part g), affording 5-(4-fluoro-3-pyridin-4-ylphenyl)-2-trifluoromethyl[1,8]naphthyridine (88 mg, 55%). δH (360 MHz, CDCl3) 7.41-7.47 (1H, m), 7.52-7.63 (5H, m), 7.85 (1H, d, J 8.8), 8.52 (1H, d, J 8.4), 8.73-8.74 (2H, m), 9.30 (1H, d, J 4.2). m/z (ES+) 370 [MH]+.