HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-5-fluorobenzonitrile → 4,2'-Difluoro-5'-nitrobiphenyl-2-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-5-fluorobenzonitrile | HCID 93654 | — |
| Reactant | 2-Fluoro-5-nitrophenylboronic acid, pinacol ester | HCID 3833297 | — |
| Product | 4,2'-Difluoro-5'-nitrobiphenyl-2-carbonitrile | HCID 11242411 | — |
Reaction Steps
2-Bromo-5-fluorobenzonitrile was coupled to 2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane as described in Example 7 part c) to give 4,2′-difluoro-5′-nitrobiphenyl-2-carbonitrile as a black solid: δH (360 MHz, CDCl3) 7.38-7.56 (4H, m), 8.33-8.40 (2H, m).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06960598B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-cbf16d3851df44e3b2d2c00967111a53 |
| Source note | uspto-grants-2005_11 |