反应详情

5-Chloro-2-trifluoromethyl[1,8]naphthyridine (50 mg, 0.22 mmol) was coupled to 5′-(5,5-dimethyl-[1,3,2]dioxaborinan-2-yl)-4,2′-difluorobiphenyl-2-carbonitrile (77 mg, 0.24 mmol) as described in Example 7 part g), affording 4,2′-difluoro-5′-(7-trifluoromethyl-[1,8]naphthyridin-4-yl)biphenyl-2-carbonitrile (13 mg, 14%). δH (400 MHz, CDCl3) 7.41-7.49 (2H, m), 7.54-7.63 (5H, m), 7.88 (1H, d, J 9.0), 8.68 (1H, d, J 8.2), 9.29 (1H, d, J 4.3). m/z (ES+) 412 [MH]+.