5-chloro-2-(trifluoromethyl)-1,8-Naphthyridine → HCID 10135167, compound

Participants

Reaction Steps

5-Chloro-2-trifluoromethyl[1,8]naphthyridine (50 mg, 0.22 mmol) was coupled to 5′-(5,5-dimethyl[1,3,2]dioxaborinan-2-yl)-2′-fluorobiphenyl-3-carbonitrile (87 mg, 0.28 mmol) as described in Example 7 part g), affording 2′-fluoro-5′-(7-trifluoromethyl-[1,8]naphthyridin-4-yl)biphenyl-3-carbonitrile (9 mg, 11%). δH (360 MHz, CDCl3) 7.41-7.46 (1H, m), 7.51-7.63 (4H, m), 7.72 (1H, d, J 7.7), 7.79-7.87 (2H, m), 7.91 (1H, d, J 1.1), 8.52 (1H, d, J 8.8), 9.30 (1H, d, J 4.2). m/z (ES+) 394 [MH]+.

Provenance & Evidence