5-chloro-2-(trifluoromethyl)-1,8-Naphthyridine → HCID 10160833, compound

Participants

Reaction Steps

5-Chloro-2-trifluoromethyl[1,8]naphthyridine (50 mg, 0.22 mmol) was coupled to 2-(2-fluoro-2′-(methanesulfonyl)biphenyl-5-yl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (105 mg, 0.28 mmol) as described in Example 7 part g), affording 5-(6-fluoro-2′-methanesulfonylbiphenyl-3-yl)-2-trifluoromethyl[1,8]-naphthyridine (32 mg, 33%). δH (360 MHz, CDCl3) 2.97 (3H, s), 7.38-7.46 (2H, m), 7.54-7.74 (5H, m), 7.87 (1H, d, J 8.4), 8.26 (1H, dd, J 1.2 and 7.9), 8.79 (1H, d, J 8.4), 9.27 (1H, d, J 4.2). m/z (ES+) 447 [MH]+.

Provenance & Evidence