HCID 2757034, compound → HCID 10156605, compound

Participants

Reaction Steps

3-Bromo-3′-methoxybiphenyl (prepared as described in patent WO 0130764) was converted to 2-(3′-methoxybiphenyl-3-yl)-5,5-dimethyl[1,3,2]-dioxaborinane using the procedure described in Example 7 part f). The crude product of this transformation (83 mg, 0.28 mmol) was coupled to 5-chloro-2-trifluoromethyl[1,8]-naphthyridine (50 mg, 0.22 mmol) as described in Example 7 part g), affording 5-(3′-methoxybiphenyl-3-yl)-2-trifluoromethyl[1,8]naphthyridine (11 mg, 13%). δH (360 MHz, CDCl3) 3.87 (3H, s), 6.95 (1H, m), 7.14-7.25 (2H, m), 7.40 (1H, t, J 7.9), 7.47 (1H, d, J 7.7), 7.56-7.69 (3H, m), 7.77-7.83 (2H, m), 8.59 (1H, d, J 8.8), 9.29 (1H, d, J 4.2). m/z (ES+) 381 [MH]

Provenance & Evidence