2,4-Dichloropyrimidine → 2-Chloro-4-(2-fluoro-5-nitrophenyl)pyrimidine

Participants

Reaction Steps

2,4-Dichloropyrimidine (2.0 g, 13 mmol) was coupled to 2-(2-fluoro-5-nitrophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane (3.9 g, 15 mmol) using the method in Example 14 part a). Purification by chromatography on silica gel eluting with dichloromethane containing 20% isohexane gave 2-chloro-4-(2-fluoro-5-nitro-phenyl)pyrimidine as a white solid: δH (400 MHz, CDCl3) 7.40 (1H, dd, J 10 and 9), 7.85 (1H, dd, J 5 and 2), 8.38-8.43 (1H, m), 8.77 (1H, d, J 6), 9.16 (1H, q, J 3).

Provenance & Evidence