反应详情

5-Chloro-2-trifluoromethyl[1,8]naphthyridine (50 mg, 0.22 mmol) was coupled to 2-(3-furan-2-ylphenyl)-5,5-dimethyl[1,3,2]-dioxaborinane (72 mg, 0.28 mmol) as described in Example 7 part g), affording 5-(3-furan-2-ylphenyl)-2-trifluoromethyl[1,8]naphthyridine (36 mg, 49%). δH (360 MHz, CDCl3) 6.53 (1H, q, J 1.8), 6.75 (1H, d, J 3.2), 7.35-7.38 (1H, m), 7.51 (1H, d, J 1.1), 7.55-7.62 (2H, m), 7.79-7.86 (3H, m), 8.57 (1H, d, J 8.4), 9.29 (1H, d, J 4.2). m/z (ES+) 341 [MH]+.