5-chloro-2-(trifluoromethyl)-1,8-Naphthyridine → HCID 10199830, compound

Participants

Reaction Steps

5-Chloro-2-trifluoromethyl[1,8]naphthyridine (50 mg, 0.22 mmol) was coupled to 2-[3-(5,5-dimethyl[1,3,2]dioxaborinan-2-yl)phenoxymethyl]pyridine (83 mg, 0.28 mmol) as described in Example 7 part g), affording 5-[3-(pyridin-2-ylmethoxy)phenyl]-2-trifluoromethyl[1,8]naphthyridine (36 mg, 34%). δH (360 MHz, CDCl3) 5.28 (2H, s), 7.07-7.11 (2H, m), 7.20 (1H, dd, J 2.1 and 8.4), 7.23-7.30 (1H, m), 7.47-7.56 (3H, m), 7.73-7.78 (2H, m), 8.50 (1H, d, J 8.8), 8.61 (1H, d, J 4.6), 9.26 (1H, d, J 4.6). m/z (ES+) 382 [MH]+.

Provenance & Evidence