5-chloro-2-(trifluoromethyl)-1,8-Naphthyridine → HCID 10222033, compound

Participants

Reaction Steps

5-Chloro-2-trifluoromethyl[1,8]naphthyridine (50 mg, 0.22 mmol) was coupled to 4-[5-(5,5-dimethyl[1,3,2]dioxaborinan-2-yl)-2-fluorobenzyl]morpholine (86 mg, 0.28 mmol) as described in Example 7 part g), affording 5-(4-fluoro-3-morpholin-4-ylmethylphenyl)-2-trifluoromethyl[1,8]naphthyridine (10 mg, 12%). δH (360 MHz, CDCl3) 2.54 (4H, t, J 4.2), 3.68 (2H, s), 3.71 (4H, t, J 4.4), 7.26 (1H, t, 8.8), 7.37 (1H, m), 7.55-7.58 (2H, m), 7.82 (1H, d, J 8.4), 8.49 (1H, d, J 8.4), 9.27 (1H, d, J 4.2). m/z (ES+) 392 [MH]+.

Provenance & Evidence