5-chloro-2-(trifluoromethyl)-1,8-Naphthyridine → 6,2'-Difluoro-5'-(7-trifluoromethyl[1,8]naphthyridin-4-yl)biphenyl-3-carbonitrile

참여 물질

반응 단계

5-Chloro-2-trifluoromethyl[1,8]naphthyridine (50 mg, 0.22 mmol) was coupled to 6,2′-difluoro-5′-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)biphenyl-3-carbonitrile (96 mg, 0.28 mmol) as described in Example 7 part g), affording 6,2′-difluoro-5′-(7-trifluoromethyl[1,8]naphthyridin-4-yl)biphenyl-3-carbonitrile (24 mg, 27%). δH (400 MHz, CDCl3) 7.35 (1H, t, J 9.0), 7.45 (1H, t, J 9.0), 7.52-7.61 (3H, m), 7.74-7.78 (1H, m), 7.83 (1H, dd, J 1.4 and 6.5), 7.87 (1H, d, J 8.6), 8.54 (1H, d, J 8.2), 9.30 (1H, d, J 4.3). m/z (ES) 412 [MH]+.

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