(3-Acetamidophenyl)boronic acid → N-[2'-fluoro-5'-(7-trifluoromethyl[1,8]naphthyridin-4-yl)biphenyl-3-yl]acetamide

Participants

Reaction Steps

Trifluoromethanesulfonic acid 2-fluoro-5-(7-trifluoromethyl[1,8]naphthyridin-4-yl)phenyl ester (30.0 mg, 0.068 mmol) was coupled to 3-acetamidophenyl-boronic acid (15.9 mg, 0.089 mmol) as described in Example 35 part c), affording N-[2′-fluoro-5′-(7-trifluoromethyl[1,8]naphthyridin-4-yl)biphenyl-3-yl]acetamide (12.0 mg, 41%). δH (360 MHz, CDCl3) 2.20 (3H, s), 7.35-7.47 (5H, m), 7.54-7.60 (2H, m), 7.84 (1H, d, J 8.4), 7.87 (1H, s), 8.56 (1H, d, J 8.8), 9.28 (1H, d, J 4.6). m/z (ES+) 426 [MH]+.

Provenance & Evidence