2-(Tributylstannyl)pyrazine → HCID 10270477, compound

Participants

Reaction Steps

Trifluoromethanesulfonic acid 2-fluoro-5-(7-trifluoromethyl[1,8]naphthyridin-4-yl)phenyl ester (30.0 mg, 0.068 mmol) was coupled to 2-tributylstannylpyrazine (50.2 mg, 0.14 mmol) as described in Example 42, affording 5-(4-fluoro-3-pyrazin-2-ylphenyl)-2-trifluoromethyl[1,8]naphthyridine (8.4 mg, 33%). δH (360 MHz, CDCl3) 7.46 (1H, dd, J 10.5 and 8.4), 7.56-7.61 (1H, m), 7.63 (1H, d, J 4.2), 7.85 (1H, d, J 8.4), 8.24 (1H, dd, J 2.3 and 7.2), 8.55 (1H, d, J 8.8), 8.60 (1H, d, J 2.5), 8.68-8.69 (1H, m), 9.23 (1H, t, J 1.9), 9.30 (1H, d, J 4.6). m/z (ES+) 371 [MH]+.

Provenance & Evidence