2′-Fluoro-5′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[1,1′-biphenyl]-2-carbonitrile → HCID 10201108, compound

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Reaction Steps

This was prepared in 88% yield from 5-chloro-2-(pyridin-3-yl)-[1,8]naphthyridine (from step a) and 2′-fluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile (from Example 2, step e) using a similar procedure to that described in Example 55, step a. δH (400 MHz, CDCl3) 7.44-7.52 (3H, m), 7.55 (1H, td, J 7.4, 1.2), 7.61-7.65 (3H, m), 7.71 (1H, td, J 7.4, 1.2), 7.85 (1H, dd, J 7.8, 1.2), 8.06 (1H, d, J 9.0), 8.59 (1H, d, J 8.6), 8.71-8.75 (2H, m), 9.20 (1H, d, J 4.7), 9.46 (1H, d, J 1.6). m/z (ES+) 403 [MH]+.

Provenance & Evidence