2′-Fluoro-5′-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)[1,1′-biphenyl]-2-carbonitrile → HCID 10136133, compound

Participants

Reaction Steps

This was prepared in 59% yield from 5-chloro-2-(thiazol-2-yl)-[1,8]naphthyridine (from step a) and 2′-fluoro-5′-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile (from Example 2, step e) using a similar procedure to that described in Example 55, step a. δH (400 MHz, CDCl3) 7.45 (1H, t, J 9.0), 7.51 (1H, d, J 4.3), 7.54 (1H, td, J 7.4, 1.2), 7.58 (1H, d, J 3.1), 7.60-7.63 (3H, m), 7.71 (1H, td, J 7.4, 1.2), 7.84 (1H, dd, J 7.4, 1.2), 8.02 (1H, d, J 3.1), 8.48 (1H, d, J 8.6), 8.54 (1H, d, J 8.6), 9.46 (1H, d, J 4.7). m/z (ES+) 409 [MH]+.

Provenance & Evidence