HCID 10429739, compound → HCID 22285782, compound

Participants

Reaction Steps

300 mg (0.79 m mol) of 2-(4-aminosulfonylphenyl)-3-(4-methoxyphenyl)indole prepared in Example 70 was suspended in 20 ml of CH2Cl2 cooled in an ice-salt bath and the cold solution of 0.41 ml (4.4 m mol) of BBR3 in 5 ml of CH2Cl2 was added in dropwise. When addition was complete, the ice-salt bath was removed and the reaction mixture was stirred at room temperature for 3 h. The solvent was removed and the residue was purified by column chromtography eluting with 3:1 petroleum: ethyl acetate to give 180 mg of title compound as light yellow crystal, yield 62.31%, m.p. 241-243° C. The data of Nuclear Magnetic Resonance shown that: 1HNMR (300 MHz, DMSO)δ:6.80-7.77 (m, 11H, Ar—H), 9.43 (s, 1H, OH), 11.56 (s, 1H, N—H); Anal. Calcd for: C20H16N2O3S: C 56.92, H 4.43, N 7.69; Found: C 56.81, H 4.34, N 7.47.

Provenance & Evidence