Azobisisobutyronitrile → HCID 22285068, compound

Participants

Reaction Steps

Methyl 6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-3-methyl-2-naphthoate (5.93 g) was suspended in carbon tetrachloride (150 ml) and N-bromosuccinimide (2.01 g) and 2,2′-azobisisobutyronitrile (0.17 g) were added. The reaction mixture was heated under reflux for 4 hrs. and the solvent was concentrated. The residue was diluted with saturated aqueous sodium hydrogen carbonate and extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated to give a crude title compound (6.70 g) as a brown amorphous solid.

Provenance & Evidence