Tetrabutylammonium Fluoride → HCID 22285052, compound

Participants

Reaction Steps

(6-tert-Butyldimethylsilyloxy-5-methyl-2-naphthyl)(1-trityl-1H-imidazol-4-yl)methanone (30.0 g) was dissolved in THF (200 mL) and tetrabutylammonium fluoride (14.9 g) was added. The mixture was stirred at room temperature for 18 hrs. and the solvent was evaporated. Water was added to the residue and the mixture was extracted with ethyl acetate. The extracted layer was washed with saturated brine, dried over anhydrous magnesium sulfate and concentrated. The residue was washed with diisopropyl ether and dried to give the title compound (22.4 g) as pale-orange crystals.

Provenance & Evidence