HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → HCID 178450032, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Methyl 1-bromomethyl-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate | HCID 22285061 | — |
| Product | HCID 178450032 | HCID 178450032 | — |
Reaction Steps
By a ring closure reaction, a detritylation reaction and purification in the same manner as in Example 1 using methyl 1-bromomethyl-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate (0.62 g) and hydrazine monohydrate (0.35 ml), 8-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-2,3-dihydrobenzo[f]phthalazin-4(1H)-one (0.05 g) was obtained as a colorless amorphous solid and 8-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]benzo[f]phthalazin-4(3H)-one (0.07 g) was obtained as colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06960586B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-6c79bfc338f14d13aee3a50c00a5a0f2 |
| Source note | uspto-grants-2005_11 |