Hydrazine hydrate (1:1) → HCID 178450042, compound

Participants

Reaction Steps

By a ring closure reaction, a detritylation reaction and purification in the same manner as in Example 1 using methyl 3-bromomethyl-6-[1-hydroxy-2-methyl-1-(1-trityl-1H-imidazol-4-yl)propyl]-2-naphthoate (0.95 g) and hydrazine monohydrate (0.50 ml), 7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]-3,4-dihydrobenzo[g]phthalazin-1(2H)-one (0.05 g) was obtained as a colorless amorphous solid and 7-[1-hydroxy-1-(1H-imidazol-4-yl)-2-methylpropyl]benzo[g]phthalazin-1(2H)-one (5 mg) was obtained as a colorless amorphous solid.

Provenance & Evidence