3-Fluorophenylboronic acid → (3'-Fluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

HRID 1061912Notes

Reaction equation

HRID 1061912 reaction equation
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11](I)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2].[F:19][C:20]1[CH:21]=[C:22](B(O)O)[CH:23]=[CH:24][CH:25]=1>>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:24]2[CH:23]=[CH:22][CH:21]=[C:20]([F:19])[CH:25]=2)=[CH:10][C:9]=1[N+:15]([O-:17])=[O:16])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 27339863-Fluorophenylboronic acidHCID 23554339Tert-butyl (4-iodo-2-nitrophenyl)carbamate

Product 1

HCID 69592831(3'-Fluoro-3-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester

Procedure

Prepared from (4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example A1) and 3-fluorobenzene boronic acid according to the general procedure B. Obtained as a yellow solid (3.87 g).

Sources & evidence

ORD record
ord-db5ec387af1b4c578a98e168117d3dbd
Source dataset
uspto-grants-2005_11
Patent number
US06960578B2

Reaction notes

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