HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous chloride dihydrate → tert-Butyl {2-amino-4-[(pyridin-2-yl)ethynyl]phenyl}carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | (2-Nitro-4-pyridin-2-ylethynyl-phenyl)-carbamic acid tert.-butyl ester | HCID 69592858 | — |
| Product | tert-Butyl {2-amino-4-[(pyridin-2-yl)ethynyl]phenyl}carbamate | HCID 69592755 | 54.4% |
Reaction Steps
Prepared from (2-nitro-4-pyridin-2-ylethynyl-phenyl)-carbamic acid tert.-butyl ester (Example F8) (262 mg, 0.772 mmol) by reduction with SnCl2.2H2O (871 mg, 3.86 mmol) according to the general procedure G (method b). Obtained as a light brown solid (130 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06960578B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-bd5fe28a680d47079f33f3b308b3622d |
| Source note | uspto-grants-2005_11 |