HuagongsheHuagongshe Chemistry Print Report · For research reference only
Stannous chloride dihydrate → [2-Amino-4-(2,4-difluoro-phenylethynyl)-phenyl]-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Stannous chloride dihydrate | HCID 61436 | — |
| Reactant | [4-(2,4-Difluoro-phenylethynyl)-2-nitro-phenyl]-carbamic acid tert.-butyl ester | HCID 69592795 | — |
| Product | [2-Amino-4-(2,4-difluoro-phenylethynyl)-phenyl]-carbamic acid tert.-butyl ester | HCID 69592763 | 99.9% |
Reaction Steps
Prepared from [4-(2,4-difluoro-phenylethynyl)-2-nitro-phenyl]-carbamic acid tert.-butyl ester (Example F11) (750 mg, 2 mmol) by reduction with SnCl2.2H2O (2.26 g, 10 mmol) according to the general procedure G (method b). Obtained as a brown solid (688 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06960578B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-c953e1fd518c4289843e04744d5f822a |
| Source note | uspto-grants-2005_11 |