Sulfuric Acid → HCID 22224674, compound

Participants

Reaction Steps

The 3-(3-iodo-phenyl)-3-oxo-propionic acid was prepared from 3-iodobenzoyl chloride (21.0 g, 78.8 mmol) and bis(trimethylsilyl)malonate (21.0 mL, 82.8 mmol) with Et3N (23 mL, 165.5 mmol) and LiBr (7.54 g, 86.7 mmol) in CH3CN at 0° C. according to general procedure H (method c1). The crude material (21.9 g) was transformed into the title compound by stirring in isopropenyl acetate and conc. H2SO4 according to general procedure J (method a). Obtained as a yellow solid (9.6 g).

Provenance & Evidence