HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → HCID 14849727, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | m-Anisoyl chloride | HCID 74374 | — |
| Reactant | Lithium Bromide | HCID 82050 | — |
| Reactant | 2,2-Bis(trimethylsilyl)propanedioate | HCID 22224580 | — |
| Solvent | Isopropenyl acetate | HCID 7916 | — |
| Product | HCID 14849727 | HCID 14849727 | — |
| Product | HCID 22224592 | HCID 22224592 | — |
Reaction Steps
The 3-(3-methoxy-phenyl)-3-oxo-propionic acid was prepared from 3-methoxybenzoyl chloride (10.3 g, 60.4 mmol) and bis(trimethylsilyl)malonate (16.2 mL, 63.4 mmol) with Et3N (17.7 mL, 127 mmol) and LiBr (5.77 g, 66.4 mmol) in CH3CN at 0° C. according to general procedure H (method c1). The crude material (6.38 g) was transformed into the title compound by stirring in isopropenyl acetate and conc. H2SO4 according to general procedure J (method a). Obtained as a yellow oil (640 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06960578B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-5d78f3cc51c74388a8e23aa6b8462695 |
| Source note | uspto-grants-2005_11 |