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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1062029Generated: October 30, 2026

Trifluoroacetic anhydride → 6-(2-Imidazol-1-yl-pyridin-4-yl)-2,2-dimethyl-[1,3]dioxin-4-one

https://huagongshe.com/reaction/1062029

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic anhydrideHCID 9845—
ReactantHCID 69592810HCID 69592810—
SolventTFA acetoneHCID 86586799—
Product6-(2-Imidazol-1-yl-pyridin-4-yl)-2,2-dimethyl-[1,3]dioxin-4-oneHCID 22224862—

Reaction Steps

Prepared from 3-(2-imidazol-1-yl-pyridin-4-yl)-3-oxo-propionic acid tert.-butyl ester (Example H5) by stirring in TFA/acetone with TFAA according to general procedure J (method b). Obtained as a brown solid (10.8 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06960578B2
Source datasetuspto-grants-2005_11
ORD IDord-b58b5ea3504b474f9d1a1192bc876991
Source noteuspto-grants-2005_11