HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Amino-4-phenylethynyl-phenyl)-carbamic acid tert-butyl ester → {2-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-phenylethynyl-phenyl}-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Amino-4-phenylethynyl-phenyl)-carbamic acid tert-butyl ester | HCID 11404065 | — |
| Reactant | 3-(2,2-Dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile | HCID 11736337 | — |
| Product | {2-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-phenylethynyl-phenyl}-carbamic acid tert.-butyl ester | HCID 11167526 | 77.5% |
Reaction Steps
Prepared from (2-amino-4-phenylethynyl-phenyl)-carbamic acid tert.-butyl ester (Example G2) (214 mg, 0.7 mmol) and 3-(2,2-dimethyl-6-oxo-6H-[1,3]dioxin-4-yl)-benzonitrile (Example J4) (250 mg, 1.1 mmol) according to the general procedure K. Obtained as a light yellow solid (260 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06960578B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-edb19e7014444f22af70b0e0b37aa1c8 |
| Source note | uspto-grants-2005_11 |