HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(3-cyanophenyl)-3-oxopropanoate → {2-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-thiazol-2-ylethynyl-phenyl}-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(3-cyanophenyl)-3-oxopropanoate | HCID 11622629 | — |
| Reactant | (2-Amino-4-thiazol-2-ylethynyl-phenyl)-carbamic acid tert.-butyl ester | HCID 69592761 | — |
| Product | {2-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-thiazol-2-ylethynyl-phenyl}-carbamic acid tert.-butyl ester | HCID 86588000 | 94.7% |
Reaction Steps
Prepared from (2-amino-4-thiazol-2-ylethynyl-phenyl)-carbamic acid tert.-butyl ester (Example G11) (89 mg, 0.28 mmol) and 3-(3-cyano-phenyl)-3-oxo-propionic acid ethyl ester (Pol. J. Chem. 1978, 25) (74 mg, 0.34 mmol) according to the general procedure K. Obtained as a light yellow solid (129 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06960578B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-0bff647cfa8648deb6dfcfbac1abd399 |
| Source note | uspto-grants-2005_11 |