HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(3-cyanophenyl)-3-oxopropanoate → {4-Benzoyl-2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-phenyl}-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(3-cyanophenyl)-3-oxopropanoate | HCID 11622629 | — |
| Reactant | Carbamic acid,(2-amino-4-benzoylphenyl)-,1,1-dimethylethyl ester | HCID 69592848 | — |
| Product | {4-Benzoyl-2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-phenyl}-carbamic acid tert.-butyl ester | HCID 86588007 | 29.3% |
Reaction Steps
Prepared from (2-amino-4-benzoyl-phenyl)-carbamic acid tert.-butyl ester (Example G24) (375 mg, 1.20 mmol) and 3-(3-cyano-phenyl)-3-oxo-propionic acid ethyl ester (Pol. J. Chem. 1978, 25) (313 mg, 1.44 mmol) according to the general procedure K. Obtained as a light yellow solid (170 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06960578B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-7dda4dcacc8d4ad2b238c91ced786e68 |
| Source note | uspto-grants-2005_11 |