HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-(3-cyanophenyl)-3-oxopropanoate → {3-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4'-trifluoromethoxy-biphenyl-4-yl}-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-(3-cyanophenyl)-3-oxopropanoate | HCID 11622629 | — |
| Reactant | Carbamic acid,[3-amino-4'-(trifluoromethoxy)[1,1'-biphenyl]-4-yl]-,1,1-dimethylethyl ester | HCID 69592772 | — |
| Product | {3-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4'-trifluoromethoxy-biphenyl-4-yl}-carbamic acid tert.-butyl ester | HCID 86588012 | — |
Reaction Steps
Prepared from (3-amino-4′-trifluoromethoxy-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G27) and 3-(3-cyano-phenyl)-3-oxo-propionic acid ethyl ester (Pol. J. Chem. 1978, 25) according to the general procedure K. Obtained as a brown semisolid (94 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06960578B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-3ec5184370cb4e579de70efa2e5aa0fe |
| Source note | uspto-grants-2005_11 |