HRID1062075

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC1(C)OC(=O)C=C(c2cccc(-n3ccnc3)c2)O1

HCID22224895

未命名化合物

结构：CC(C)(C)OC(=O)Nc1ccc(-c2ccc(OCc3ccccc3)nc2)cc1N

HCID69592766

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)Nc1ccc(-c2ccc(OCc3ccccc3)nc2)cc1NC(=O)CC(=O)c1cccc(-n2ccnc2)c1

HCID86588032

未命名化合物

收率 69.2%

PROCEDURE

实验过程

Prepared from [2-amino-4-(6-benzyloxy-pyridin-3-yl)-phenyl]-carbamic acid tert.-butyl ester (Example G30) (196 mg, 0.5 mmol) and 6-(3-imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J10) (229 mg, 0.85 mmol) according to the general procedure K. Obtained as a yellow solid (209 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6a0f34727ddb4af6a304549562ff87d6
来源数据集: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06960578B2
来源说明: uspto-grants-2005_11

反应 SMILES

[C:1]([O:5][C:6](=[O:29])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[N:16][C:17]([O:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[CH:18][CH:19]=2)=[CH:10][C:9]=1[NH2:28])([CH3:4])([CH3:3])[CH3:2].[N:30]1([C:35]2[CH:36]=[C:37]([C:41]3[O:46]C(C)(C)[O:44][C:43](=O)[CH:42]=3)[CH:38]=[CH:39][CH:40]=2)[CH:34]=[CH:33][N:32]=[CH:31]1>>[C:1]([O:5][C:6](=[O:29])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:15]=[N:16][C:17]([O:20][CH2:21][C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)=[CH:18][CH:19]=2)=[CH:10][C:9]=1[NH:28][C:43](=[O:44])[CH2:42][C:41]([C:37]1[CH:38]=[CH:39][CH:40]=[C:35]([N:30]2[CH:34]=[CH:33][N:32]=[CH:31]2)[CH:36]=1)=[O:46])([CH3:4])([CH3:2])[CH3:3]