6-(3-Imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one → {4-Cyclopropyl-2-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-phenyl}-carbamic acid tert.-butyl ester

HRID 1062108Notes

Reaction equation

HRID 1062108 reaction equation
[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:16][CH2:15]2)=[CH:10][C:9]=1[NH2:17])([CH3:4])([CH3:3])[CH3:2].[N:19]1([C:24]2[CH:25]=[C:26]([C:30]3[O:35]C(C)(C)[O:33][C:32](=O)[CH:31]=3)[CH:27]=[CH:28][CH:29]=2)[CH:23]=[CH:22][N:21]=[CH:20]1>>[C:1]([O:5][C:6](=[O:18])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]2[CH2:16][CH2:15]2)=[CH:10][C:9]=1[NH:17][C:32](=[O:33])[CH2:31][C:30]([C:26]1[CH:27]=[CH:28][CH:29]=[C:24]([N:19]2[CH:23]=[CH:22][N:21]=[CH:20]2)[CH:25]=1)=[O:35])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 222248956-(3-Imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-oneHCID 69592759(2-Amino-4-cyclopropyl-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 86588065{4-Cyclopropyl-2-[3-(3-imidazol-1-yl-phenyl)-3-oxo-propionylamino]-phenyl}-carbamic acid tert.-butyl ester

Procedure

Prepared from (2-amino-4-cyclopropyl-phenyl)-carbamic acid tert.-butyl ester (Example G48) and 6-(3-imidazol-1-yl-phenyl)-2,2-dimethyl-[1,3]dioxin-4-one (Example J10) according to the general procedure K. Obtained as a light yellow solid (79 mg).

Sources & evidence

ORD record
ord-40f87a1b37c0433f82479cc0dba70d23
Source dataset
uspto-grants-2005_11
Patent number
US06960578B2

Reaction notes

Loading…