HRID1062117

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1nccn1-c1cccc(C2=CC(=O)OC(C)(C)O2)c1

HCID22224790

未命名化合物

结构：CC(C)(C)OC(=O)Nc1ccc(-c2ccc(F)cc2F)cc1N

HCID69592785

未命名化合物

PRODUCTS

生成物

结构：Cc1nccn1-c1cccc(C(=O)CC(=O)Nc2cc(-c3ccc(F)cc3F)ccc2NC(=O)OC(C)(C)C)c1

HCID86588074

未命名化合物

PROCEDURE

实验过程

Prepared from (3-amino-2′,4′-difluoro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example G43) and 2,2-dimethyl-6-[3-(2-methyl-imidazol-1-yl)-phenyl]-[1,3]dioxin-4-one (Example J15) according to the general procedure K. Obtained as a yellow oil (145 mg).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-366d6bfdd906490aaffa63ca97fa8f2b
来源数据集: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06960578B2
来源说明: uspto-grants-2005_11

反应 SMILES

[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])=[CH:10][C:9]=1[NH2:22])([CH3:4])([CH3:3])[CH3:2].CC1(C)[O:30][C:29](=O)[CH:28]=[C:27]([C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([N:38]3[CH:42]=[CH:41][N:40]=[C:39]3[CH3:43])[CH:33]=2)[O:26]1>>[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])=[CH:10][C:9]=1[NH:22][C:29](=[O:30])[CH2:28][C:27]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([N:38]2[CH:42]=[CH:41][N:40]=[C:39]2[CH3:43])[CH:33]=1)=[O:26])([CH3:4])([CH3:2])[CH3:3]