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Trifluoroacetic acid → 3-(7-Furan-2-yl-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-benzonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | {2-[3-(3-Cyano-phenyl)-3-oxo-propionylamino]-4-furan-2-yl-phenyl}-carbamic acid tert.-butyl ester | HCID 86587992 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 3-(7-Furan-2-yl-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-benzonitrile | HCID 22224686 | — |
反応手順
Prepared from {2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-4-furan-2-yl-phenyl}-carbamic acid tert.-butyl ester (Example K5) by treatment with TFA in CH2Cl2 according to the general procedure M. Obtained as a brown powder (73 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06960578B2 |
| 出典データセット | uspto-grants-2005_11 |
| ORD ID | ord-fb9c5badb17e432687bdf38916e71d72 |
| 出典メモ | uspto-grants-2005_11 |