1-Ethynyl-4-methoxybenzene → 3-[7-(4-Methoxy-phenylethynyl)-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl]-benzonitrile
반응식
I[C:2]1[CH:21]=[CH:20][C:5]2[N:6]=[C:7]([C:12]3[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=3)[C:15]#[N:16])[CH2:8][C:9](=[O:11])[NH:10][C:4]=2[CH:3]=1.[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]#[CH:31])=[CH:26][CH:25]=1>>[CH3:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]#[C:31][C:2]2[CH:21]=[CH:20][C:5]3[N:6]=[C:7]([C:12]4[CH:13]=[C:14]([CH:17]=[CH:18][CH:19]=4)[C:15]#[N:16])[CH2:8][C:9](=[O:11])[NH:10][C:4]=3[CH:3]=2)=[CH:26][CH:25]=1참가 물질
3
실험 절차
Prepared from 3-(7-iodo-4-oxo-4,5-dihydro-3H-benzo[b][1,4]diazepin-2-yl)-benzonitrile (Example 1) (290 mg, 0.75 mmol) and 4-methoxy-phenylacetylene (350 mg, 1.57 mmol) according to the general procedure F. Obtained as a light yellow solid (172 mg).
출처 및 근거
- ORD 기록
- ord-b2d222a3ac33402cb05a5ea3d35ebfe8
- 출처 데이터셋
- uspto-grants-2005_11
- 특허 번호
- US06960578B2
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