反应详情

1.5a 3 g of ethyl (7-chloro-1-methyl-3-propyl-1H-pyrazolo-[4,3-d]pyrimidin-5-ylmethoxy)acetate and 1.9 g of 3-chloro-4-methoxy-benzylamine in 50 ml of dimethylformamide (DMF) are stirred at 60° for 12 hours in the presence of potassium carbonate. After filtration, the solvent is removed, and the mixture is subjected to conventional work-up, giving 4.6 g of ethyl [7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetate.

1. filtrationAfter filtration
2. customthe solvent is removed