Potassium Carbonate → ethyl [7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetate

HRID 1062314Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1062314
Cl[C:2]1[C:3]2[N:18]([CH3:19])[N:17]=[C:16]([CH2:20][CH2:21][CH3:22])[C:4]=2[N:5]=[C:6]([CH2:8][O:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:7]=1.[Cl:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][C:31]=1[O:32][CH3:33])[CH2:27][NH2:28].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:23][C:24]1[CH:25]=[C:26]([CH:29]=[CH:30][C:31]=1[O:32][CH3:33])[CH2:27][NH:28][C:2]1[C:3]2[N:18]([CH3:19])[N:17]=[C:16]([CH2:20][CH2:21][CH3:22])[C:4]=2[N:5]=[C:6]([CH2:8][O:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[N:7]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 7380383-Chloro-4-methoxybenzylamineHCID 11347981ethyl (7-chloro-1-methyl-3-propyl-1H-pyrazolo-[4,3-d]pyrimidin-5-ylmethoxy)acetate

Produkt 1

HCID 11408593ethyl [7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

1.5a 3 g of ethyl (7-chloro-1-methyl-3-propyl-1H-pyrazolo-[4,3-d]pyrimidin-5-ylmethoxy)acetate and 1.9 g of 3-chloro-4-methoxy-benzylamine in 50 ml of dimethylformamide (DMF) are stirred at 60° for 12 hours in the presence of potassium carbonate. After filtration, the solvent is removed, and the mixture is subjected to conventional work-up, giving 4.6 g of ethyl [7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetate.

Aufarbeitung

  1. filtrationAfter filtration
  2. customthe solvent is removed

Quellen und Nachweise

ORD-Eintrag
ord-e09caef14d5c49fbad3207a483730814
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06960661B2

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