HCID 69611259, compound → HCID 69611275, compound

Participants

Reaction Steps

A solution of crude tert-butyl 2-((2S,3S)-3-{[(benzyloxy)carbonyl]amino}-2-hydroxy-4-phenylbutyl)-2-ethylhydrazinecarboxylate (502 mg, 1.1 mmol) in MeOH (10 mL) was added to 10% Pd/C (5.2 mg) and stirred in a hydrogen atmosphere (@ ambient pressure) for 6 h. The reaction was filtered through Celite and the filtrate concentrated under reduced pressure to yield crude tert-butyl 2-((25,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-ethylhydrazinecarboxylate (293 mg). MS (ESI+) for C17H29N3O3 m/z 324.2 (M+H)+.

Provenance & Evidence