Isocaproic acid → HCID 10231525, compound

HRID 1062334Notes

Reaction equation

HRID 1062334 reaction equation
[NH2:1][C@@H:2]([CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C@@H:3]([OH:16])[CH2:4][N:5]([CH2:14][CH3:15])[NH:6][C:7]([O:9]C(C)(C)C)=O.[CH3:24][CH:25]([CH3:31])[CH2:26][CH2:27]C(O)=O.[CH3:32][C:33]1[CH:34]=[C:35]([C:42]([N:44]([CH2:48][CH2:49][CH3:50])[CH2:45][CH2:46][CH3:47])=[O:43])[CH:36]=[C:37]([CH:41]=1)[C:38]([OH:40])=O>>[CH2:17]([C@H:2]([NH:1][C:38](=[O:40])[C:37]1[CH:41]=[C:33]([CH3:32])[CH:34]=[C:35]([C:42]([N:44]([CH2:48][CH2:49][CH3:50])[CH2:45][CH2:46][CH3:47])=[O:43])[CH:36]=1)[C@@H:3]([OH:16])[CH2:4][N:5]([CH2:14][CH3:15])[NH:6][C:7](=[O:9])[CH2:27][CH2:26][CH:25]([CH3:31])[CH3:24])[C:18]1[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1

Participants

4

Reactant 3

HCID 12587Isocaproic acidHCID 113913935-methyl-N,N-dipropylisophthalamic acidHCID 69611275HCID 69611275, compound

Product 1

HCID 10231525HCID 10231525, compound

Procedure

Synthesized as described above from tert-butyl 2-((2S,3S)-3-amino-2-hydroxy-4-phenylbutyl)-2-ethylhydrazinecarboxylate, 4-methylpentanoic acid and 5-methyl-N,N-dipropyl-isophthalamic acid (WO 02/02512). MS (ESI+) for C33H50N4O4 m/z 567.3 (M+H)+.

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-210957cdea6941168edf62f846945008
Source dataset
uspto-grants-2005_11
Patent number
US06960664B2

Reaction notes

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