3-Methylpentanoic acid → HCID 10304220, compound

HRID 1062335Notes

Reaction equation

HRID 1062335 reaction equation
[NH2:1][C@@H:2]([CH2:17][C:18]1[CH:23]=[C:22]([F:24])[CH:21]=[C:20]([F:25])[CH:19]=1)[C@@H:3]([OH:16])[CH2:4][N:5]([CH2:14][CH3:15])[NH:6][C:7]([O:9]C(C)(C)C)=O.[CH3:26][CH:27]([CH2:32]C)[CH2:28][C:29](O)=O.[CH3:34][C:35]1[CH:36]=[C:37]([C:44]([N:46]([CH2:50][CH2:51][CH3:52])[CH2:47][CH2:48][CH3:49])=[O:45])[CH:38]=[C:39]([CH:43]=1)[C:40]([OH:42])=O>>[F:24][C:22]1[CH:23]=[C:18]([CH:19]=[C:20]([F:25])[CH:21]=1)[CH2:17][C@H:2]([NH:1][C:40](=[O:42])[C:39]1[CH:43]=[C:35]([CH3:34])[CH:36]=[C:37]([C:44]([N:46]([CH2:50][CH2:51][CH3:52])[CH2:47][CH2:48][CH3:49])=[O:45])[CH:38]=1)[C@@H:3]([OH:16])[CH2:4][N:5]([CH2:14][CH3:15])[NH:6][C:7](=[O:9])[CH2:29][CH2:28][CH:27]([CH3:32])[CH3:26]

Participants

4

Reactant 3

HCID 77553-Methylpentanoic acidHCID 113913935-methyl-N,N-dipropylisophthalamic acidHCID 69611293HCID 69611293, compound

Product 1

HCID 10304220HCID 10304220, compound

Procedure

Synthesized as described above from tert-butyl 2-((2S,3S)-3-amino-2-hydroxy-4-(3,5difluorophenyl)butyl)-2-ethylhydrazinecarboxylate, 3-methylpentanoic acid and 5-methyl-N,N-dipropyl-isophthalamic acid. MS (ESI+) for C33H48F2N4O4 m/z 603.3 (M+H)+.

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-a1443ebd8ae5492a8f77ad2c604aadef
Source dataset
uspto-grants-2005_11
Patent number
US06960664B2

Reaction notes

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