Isovaleric Acid → HCID 69611258, compound

HRID 1062336Notes

Reaction equation

HRID 1062336 reaction equation
[NH2:1][C@@H:2]([CH2:17][C:18]1[CH:23]=[C:22]([F:24])[CH:21]=[C:20]([F:25])[CH:19]=1)[C@@H:3]([OH:16])[CH2:4][N:5]([CH2:14][CH3:15])[NH:6][C:7]([O:9]C(C)(C)C)=O.[CH3:26][CH:27](C)[CH2:28][C:29](O)=O.[CH3:33][C:34]1[CH:35]=[C:36]([C:43]([N:45]([CH2:49][CH2:50][CH3:51])[CH2:46][CH2:47][CH3:48])=[O:44])[CH:37]=[C:38]([CH:42]=1)[C:39]([OH:41])=O>>[F:24][C:22]1[CH:23]=[C:18]([CH:19]=[C:20]([F:25])[CH:21]=1)[CH2:17][C@H:2]([NH:1][C:39](=[O:41])[C:38]1[CH:42]=[C:34]([CH3:33])[CH:35]=[C:36]([C:43]([N:45]([CH2:49][CH2:50][CH3:51])[CH2:46][CH2:47][CH3:48])=[O:44])[CH:37]=1)[C@@H:3]([OH:16])[CH2:4][N:5]([CH2:14][CH3:15])[NH:6][C:7](=[O:9])[CH2:26][CH2:27][CH2:28][CH3:29]

Participants

4

Reactant 3

HCID 10430Isovaleric AcidHCID 113913935-methyl-N,N-dipropylisophthalamic acidHCID 69611293HCID 69611293, compound

Product 1

HCID 69611258HCID 69611258, compound

Procedure

Synthesized as described above from tert-butyl 2-((2S,3S)-3-amino-2-hydroxy-4-(3,5difluorophenyl)butyl)-2-ethylhydrazinecarboxylate, 3-methylbutanoic acid and 5-methyl-N,N-dipropyl-isophthalamic acid. MS (ESI+) for C32H46F2N4O4 m/z 589.3 (M+H)+.

Workup

  1. customSynthesized

Sources & evidence

ORD record
ord-e091c460dc4d451381bf4de8389f045e
Source dataset
uspto-grants-2005_11
Patent number
US06960664B2

Reaction notes

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