Cesium carbonate → HCID 69729781, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl bromoacetate (0.230 g, 1.93 mmol), Cs2CO3 (0.525 g, 1.60 mmol), and N-(3-hydroxy-phenyl)-3-phenyl-acrylamide (1/91) (0.370 g, 1.55 mmol) in acetonitrile (5 ml) was stirred at 45° C. for 3 hours. The reaction mixture was evaporated and the residue was partitioned between ethyl acetate and 0.1N KHSO4. The organic layer was washed successively with water, brine, and dried (Na2SO4). The solvent was evaporated and the residue was chromatographed silicagel with chloroform-ethyl acetate (10:1) as eluent to give the title compound 8 (0.235 g, 48%). 1H NMR (CDCl3, HMDSO) δ: 3.75 (3H, s); 4.62 (2H, s); 6.53 (1H, d, J=15.6 Hz); 6.68 (1H, t, J=2.0 Hz); 7.01-7.60 (9H, m); 7.71 (1H, d, J=15.6 Hz).

Provenance & Evidence