Tert-butyl acetoacetate → CID 71354250

Participants

Reaction Steps

t-Butyl acetoacetate (5.0 g, 31.6 mmol) was dissolved in acetic acid (4.5 mL), cooled by an ice water bath, and treated with sodium nitrite (2.45 g, 35.5 mmol) in water (5.5 mL) while the internal temperature was kept at <10° C. (see, e.g., U.S. Pat. No. 4,743,586). After the addition was complete, the mixture was stirred at rt for 30 minutes before water (16 mL) was added. After 2 h, extraction with ether (3×25 mL), which was washed with water (10 mL), sodium bicarbonate solution (3×10 mL), and water (20 mL), gave t-butyl 2-hydroxyimino-3-oxobutanoate as a white solid (5.52 g, 93%): 1H NMR (300 MHz, CDCl3) δ 8.61 (s, 1H), 2.39 (s, 3H), 1.58 (s, 9H).

Provenance & Evidence