HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Diethyl N-[4-(aminomethyl)benzoyl]-L-glutamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Diethyl-N-[4-[[N-(tert-butyloxycarbonyl)amino]methyl]benzoyl]-L-glutamate | HCID 15292991 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Diethyl N-[4-(aminomethyl)benzoyl]-L-glutamate | HCID 10472190 | 88.2% |
Reaction Steps
About 1.8 ml trifluoroacetic acid was added dropwise to a stirred solution containing about 1.0 g of Compound 34 in about 20 ml CH2Cl2. The mixture was stirred at room temperature for 15 minutes, evaporated to dryness under reduced pressure, and co-evaporated twice with about 30 ml absolute ethanol. The residue was then subjected to column chromatography on silica gel (1.5×15 cm), eluting with a gradient of 5-10% methanol in CHCl3 to yield about 0.68 g of Compound 35.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06962920B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-30ba7c749bee48e4b6771ba19d31f510 |
| Source note | uspto-grants-2005_11 |