Acetic Acid → HCID 22282146, compound

Participants

Reaction Steps

A solution of 1,3-dimethyl-6-vinyl-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile (2.20 g, 11.1 mmol) in methanol (110 mL) was treated with acetic acid (635 μL, 11.1 mmol) and pyrrolidine (4.59 mL, 55.5 mmol). The mixture was stirred at room temperature for 3 hours and the solvent removed under reduced pressure. The residue was suspended in water and extracted with ethyl acetate. The combined organic layers were dried over Na2SO4 and concentrated to give 1,3-dimethyl-6-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrazolo[3,4-b]pyridine-5-carbonitrile as a tan solid.

Provenance & Evidence