Sodium Hydroxide → HCID 23400329, compound

Participants

Reaction Conditions

Reaction Steps

1,3-Dimethyl-6-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrazolo [3,4-b]pyridine-5-carbonitrile was dissolved in concentrated H2SO4 (55 mL) and the solution stirred at 60° C. for 2 days. The mixture was cooled to 0° C., treated with 6N NaOH to pH 14, and extracted with ethyl acetate. The organic extract was evaporated under reduced pressure and the residue washed with ether to give 1,3-dimethyl-6-[2-(pyrrolidin-1-yl)ethyl)-1H-pyrazolo [3,4-b]pyridine-5-carboxamide (2.5 g).

Provenance & Evidence