HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1062586Generated: October 25, 2026
Water → 6-Iodo-1-methylquinazoline-2,4(1H,3H)-dione
https://huagongshe.com/reaction/1062586
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Benzylacetylene | HCID 575753 | — |
| Reactant | HCID 22281861 | HCID 22281861 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Iodo-1-methylquinazoline-2,4(1H,3H)-dione | HCID 22281870 | — |
Reaction Steps
To 0.45 g (1.1 mmol) 3-(3,4-Difluoro-benzyl)-6-iodo-1-methyl-1H-quinazoline-2,4-dione and 0.56 g (4.4 mmol) di-isopropyl ethylamine in 15 ml DMF is added bis-triphenylphosphine palladium di-chloride (catalytic) followed by CuI (catalytic). 0.18 g (1.3 mmol) 3-phenyl-propyne is added and the mixture is heated to 70° C. for 6 hours. The mixture is allowed to cool to room temperature and stirred overnight. Water is added and the mixture stirred 30 minutes. Filtered and triturated solid in hot EtOAc and filtered. Purified by flash chromatography (EtOAc/hexane eluent).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06962922B2 |
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| Source dataset | uspto-grants-2005_11 |
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| ORD ID | ord-ed1b524242324f459348d6e56b4d954e |
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| Source note | uspto-grants-2005_11 |
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