Bromine → HCID 178508333, compound

HRID 1062597Notes

Reaction equation

HRID 1062597 reaction equation
[CH:1]1[C:6](=[O:7])[NH:5][C:4]([NH2:8])=[N:3][CH:2]=1.[Br:9]Br>C(O)(=O)C>[NH2:8][C:4]1[N:5]=[C:6]([OH:7])[C:1]([Br:9])=[CH:2][N:3]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 66950Isocytosine

Product 1

HCID 178508333HCID 178508333, compoundYield 140%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution of isocytosine(1.04 g, 9.36 mmol) in acetic acid(25 ml) are added dropwise bromine(0.51 ml, 9.83 mmol) at room temperature. After the addition is completed, the reaction mixture is stirred for 1 hour at this temperature, successively concentrated under reduced pressure to give the residue, which is washed with ethyl ether, dried to afford white powders(2.49 g, 98%).

Workup

  1. additionAfter the addition
  2. concentrationsuccessively concentrated under reduced pressure
  3. customto give the residue, which
  4. washis washed with ethyl ether
  5. customdried

Sources & evidence

ORD record
ord-8021f1d0a36e428b9f20321fccfb1df8
Source dataset
uspto-grants-2005_11
Patent number
US06962919B2

Reaction notes

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