反应详情

To a solution of isocytosine(1.04 g, 9.36 mmol) in acetic acid(25 ml) are added dropwise bromine(0.51 ml, 9.83 mmol) at room temperature. After the addition is completed, the reaction mixture is stirred for 1 hour at this temperature, successively concentrated under reduced pressure to give the residue, which is washed with ethyl ether, dried to afford white powders(2.49 g, 98%).

1. additionAfter the addition
2. concentrationsuccessively concentrated under reduced pressure
3. customto give the residue, which
4. washis washed with ethyl ether
5. customdried