HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Formylbenzoic acid → 4-[3-(2-Methoxy-4-thiophen-2-yl-phenyl)-3-oxo-E-propenyl]-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Formylbenzoic acid | HCID 12088 | — |
| Reactant | 2'-Methoxy-4'-(thien-2-yl)acetophenone | HCID 21981069 | — |
| Product | 4-[3-(2-Methoxy-4-thiophen-2-yl-phenyl)-3-oxo-E-propenyl]-benzoic acid | HCID 21981106 | — |
Reaction Steps
The title compound was prepared by condensing 1-(2-methoxy-4-thiophen-2-yl-phenyl)-ethanone (Ex-19A) and 4-carboxybenzaldehyde in a similar manner as described in Ex-17 except an acidic workup. Yellow solid, mp 193–195° C. 1H-NMR (CDCl3) □ 7.70 (d, J=8 Hz, 2H), 7.38 (d, J=8 Hz, 1H), 7.07–7.16 (m, 4H), 6.75–6.80 (m, 4H), 6.42 (d, J=16 Hz, 1H), 3.67 (s, 3H), MS m/z=364 ([M]+, 100%). Anal. Calculated for C21H16O4S: C, 69.21; H, 4.43; S, 8.80; found: C, 69.02; H, 4.56; S, 8.75.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07094801B2 |
| Source dataset | uspto-grants-2006_08 |
| ORD ID | ord-e7d528ac61244a92ae77ef18a8dc8431 |
| Source note | uspto-grants-2006_08 |