Water → HCID 11315915, compound

HRID 1062623Notes

Reaction equation

HRID 1062623 reaction equation
[CH3:1][C:2]([C:5]1[CH:10]=[CH:9][C:8]([C:11](=[O:19])[CH2:12][C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:7][CH:6]=1)([CH3:4])[CH3:3].[Br:20]Br.O>C(O)(=O)C>[BrH:20].[Br:20][CH:12]([C:13]1[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=1)[C:11]([C:8]1[CH:9]=[CH:10][C:5]([C:2]([CH3:1])([CH3:3])[CH3:4])=[CH:6][CH:7]=1)=[O:19]

Participants

5

Reactant 3

HCID 962WaterHCID 24408BromineHCID 104674521-[4-(1,1-DIMETHYLETHYL)PHENYL]-2-(4-PYRIDYL)ETHANONE

Product 1

HCID 11315915HCID 11315915, compoundYield 119.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
80 °C

Procedure

1-[4-(1,1-Dimethylethyl)phenyl]-2-(4-pyridyl)ethanone (10 g, 39 mmol) was dissolved in acetic acid (40 mL) and bromine (2.0 mL, 39 mmol) was added. The mixture was stirred at 80° C. for 3 h. The reaction mixture was cooled with iced water and the precipitated crude crystals were collected by filtration. The crude crystals were washed with ethyl acetate to give the title compound (9.6 g, yield 81%).

Workup

  1. customthe precipitated crude crystals
  2. filtrationwere collected by filtration
  3. washThe crude crystals were washed with ethyl acetate

Sources & evidence

ORD record
ord-f4bd80bc9c6b4b319f78dc9c59c4b919
Source dataset
uspto-grants-2005_11
Patent number
US06962933B1

Reaction notes

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