4-(t-Butoxycarbonyl)amino-2'-methylsulfonyl-[1,1']biphenyl → 4-(2-Methylsulfonylphenyl)aniline

Participants

Reaction Steps

4-(t-butoxycarbonyl)amino-2′-methylsulfonyl-[1,1′]biphenyl (4.6 g, 13 mmol), was suspended in 100 mL of 4M HCl in dioxane and stirred 2.5 days. The resulting mixture was filtered and the cake rinsed with Et2O to yield a tan solid (3.69 g, 98%). 1H NMR (DMSO-d6) δ: 8.04 (d, 1H), 7.71 (t, 1H), 7.61 (t, 1H), 7.31 (m, 3H), 7.06 (m, 2H), 2.79 (s, 3H).

Provenance & Evidence